Adib M, Peytam F, Shourgeshty R, Mohammadi-Khanaposhtani M, Jahani M, Imanparast S, Faramarzi MA, Larijani B, Moghadamnia AA, Esfahani EN, Bandarian F.
Bioorganic & medicinal chemistry letters. 2019 Mar 1;29(5):713-8.

Twenty three fused carbazole–imidazoles 6a–w were designed, synthesized, and screened as new α-glucosidase inhibitors. All the synthesized fused carbazole-imidazoles 6a-w were found to be more active than acarbose (IC50 = 750.0 ± 1.5 µM) against yeast α-glucosidase with IC50 values in the range of 74.0 ± 0.7–298.3 ± 0.9 µM. Kinetic study of the most potent compound 6v demonstrated that this compound is a competitive inhibitor for α-glucosidase (Ki value = 75 µM). Furthermore, the in silico studies of the most potent compounds 6v and 6o confirmed that these compounds interacted with the key residues in the active site of α-glucosidase.

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